主な論文発表
Tsukita,Sh. and Ishikawa,H. 1979.
Morphological evidence for the involvement of the smooth endoplasmic
reticulum in axonal transport.
Brain Res. 174:315-318.
Tsukita,Sh. and Ishikawa,H. 1980.
The movement of membranous organelles in axons. Electron microscopic
identification of anterogradely and retrogradely transported organelles.
J.Cell Biol. 84:513-530.
Tsukita,Sa., Tsukita,Sh. and Ishikawa,H. 1980.
Cytoskeletal network underlying the human erythrocyte membrane.
Thin-section electron microscopy.
J.Cell Biol. 85:567-576.
Tsukita,Sh., Ishikawa,H. and Kurokawa,M. 1981.
Isolation of 10-nm filaments from astrocytes in the mouse optic nerve.
J.Cell Biol. 88:245-250.
Tsukita,Sa., Tsukita,Sh., Ishikawa,H., Sato,S., and Nakao,M. 1981.
Electron microscopic study of reassociation of spectrin and actin with the human
erythrocyte membrane.
J.Cell Biol. 90:70-77.
Tsukita,Sh., Tsukita,Sa., Usukura,J. and Ishikawa,H. 1983.
ATP-dependent structural changes of the outer dynein arm in Tetrahymena
cilia: A freeze-etch replica study.
J.Cell Biol. 96:1480-1485.
Tsukita,Sa., Tsukita,Sh., Ishikawa,H., Kurokawa,M., Morimoto,K., Sobue,K. and
Kakiuchi,S. 1983.
Binding sites of calmodulin and actin on the brain spectrin, calspectin.
J.Cell Biol. 97:574-578.
Tsukita,Sa., Tsukita,Sh. and Ishikawa,H. 1984.
Bidirectional polymerization of G-actin on the human erythrocyte
membrane
J.Cell Biol. 98:1102-1110.
Stadler,H. and Tsukita,Sh. 1984.
Synaptic vesicles contain an ATP-dependent proton pump and show 'knob-
like' protrusions on their surface.
EMBO J. 3:3333-3337.
Mabuchi,I., Hamaguchi,Y., Kobayashi,T., Hosoya,H., Tsukita,Sa. and Tsukita,Sh.
1985.
Actinin from sea urchin eggs: Biochemical properties, interaction with actin and
distributionin the cell during fertilization and cleavage.
J.Cell Biol. 100:375-383.
Tsukita,Sh. and Yano,M. 1985.
Actomyosin structure in contracting muscle detected by rapid freezing.
Nature 317:182-184.
Tsukita,Sa. and Tsukita,Sh. 1985.
Desmocalmin: A calmodulin-binding high molecular weight protein isolated
from desmosomes.
J.Cell Biol. 101:2070-2080.
Kobayashi,T., Tsukita,Sh., Tsukita,Sa., Yamamoto,Y., and Matsumoto,G.
1986.
Subaxolemmal cytoskeleton in squid giant axon. I.Biochemical analysis of
microtubules, microfilaments, and their associated high-molecular-weight
proteins.
J.Cell Biol. 102:1699-1709.
Tsukita,Sh., Tsukita,Sa., Kobayashi,T. and Matsumoto,G. 1986.
Subaxolemmal cytoskeleton in squid giant axon. II.Morphological
identification of microtubule- and microfilament-associated domains of
axolemma.
J.Cell Biol. 102:1710-1725.
Okamura,Y. and Tsukita,Sh. 1986.
Morphology of freeze-substituted myelinated axon in mouse peripheral
nerves.
Brain Res. 383:146-158.
Tsukita,Sa., Tsukita,Sh. and Matsumoto,G. 1988.
Light-induced structural changes of cytoskeleton in squid photoreceptor
microvilli detected by rapid freezing.
J.Cell Biol. 106:1151-1160.
Tsukita,Sh. and Tsukita,Sa. 1989.
Isolation of cell-to-cell adherens junction from rat liver.
J.Cell Biol. 108:31-41.
Tsukita,Sa., Hieda,Y. and Tsukita,Sh. 1989.
A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell
adherens junction: Purification and characterization.
J.Cell Biol. 108:2369-2382.
Hieda,Y., Tsukita,Sa. and Tsukita,Sh. 1989.
A new high molecular mass protein showing unique localization in
desmosomal plaque.
J.Cell Biol. 109:1511-1518.
Tsukita,Sh., Itoh,M., and Tsukita,Sa. 1989.
A new 400kD-protein from isolated adherens junctions: Its localization at the
undercoat of adherens junctions and at microfilament bundles such as stress
fibers and circumferential bundles.
J.Cell Biol. 109:2905-2915.
Sato,N., Yonemura,S., Obinata,T., Tsukita,Sa. and Tsukita,Sh. 1991.
Radixin, a barbed-end-capping actin-modulating protein, is concentrated at the
cleavage furrow during cytokinesis.
J.Cell Biol. 113:321-330.
Tsukita,Sa., Oishi,K., Akiyama,T., Yamanashi,Y., Yamamoto,T., and
Tsukita,Sh. 1991.
Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell
adherens junctions, where the level of tyrosine phosphorylation is elevated.
J.Cell Biol. 113:867-879.
Nagafuchi,A., Takeichi,M. and Tsukita,Sh. 1991.
The 102kd cadherin-associated protein: Similarity to vinculin and post-
transcriptional regulation of expression.
Cell 65:1-20.
Funayama,N., Nagafuchi,A., Sato,N., Tsukita,Sa., and Tsukita,Sh. 1991.
Radixin is a novel member of the band 4.1 family.
J.Cell Biol. 115:1039-1048.
Itoh,M., Yonemura,S., Nagafuchi,A., Tsukita,Sa., and Tsukita,Sh. 1991.
A 220kD undercoat-constitutive protein: Its specific localization at cadherin-
based cell-to-cell adhesion sites.
J.Cell Biol. 115:1449-1462.
Sato,N., Funayama,N., Nagafuchi,A., Yonemura,S., Tsukita,Sa., and Tsukita, Sh.
1992.
A gene family consisting of ezrin, radixin, and moesin. Its specific localization at
actin/plasma membrane association sites.
J.Cell Sci. 103:131 -143.
Tsukita,Sh., Tsukita,Sa., Nagafuchi,A., and Yonemura,Sh. 1992.
Molecular linkage between cadherins and actin filaments in cell-to-cell
adherens junctions.
Curr.Opin.Cell Biol. 4:834-839.
Yonemura,S., Nagafuchi,A., Sato,N., and Tsukita,Sh. 1993.
Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin),
in the cleavage furrow through the interaction of its cytoplasmic domain with
actin-based cytoskeletons.
J.Cell Biol. 120:437-449.
Funatsu,T., Kono,E., Higuchi,H., Kimura,S., Ishiwata,S., Yoshioka,T.,
Maruyama,K., and Tsukita,Sh. 1993.
Elastic filaments in situ in cardiac muscle: Deep-etch replica analysis in
combination with selective removal of actin and myosin filaments.
J.Cell Biol. 120:711-724.
Itoh,M., Nagafuchi,A., Yonemura,S., Yasuda-Kitani,T., Tsukita,Sa., and
Tsukita,Sh. 1993.
The 220kD protein colocalizing with cadherins in non-epithelial cells is
identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA
cloning and immunoelectron microscopy.
J.Cell Biol. 121:491-502.
Funatsu,T., Kono,E., and Tsukita,Sh. 1993.
Time-resolved electron microscopic analysis of the behavior of myosin heads on
actin filaments after photolysis of caged ATP.
J.Cell Biol. 121:1053-1064.
Tsukita,Sh., Itoh,M., Nagafuchi,A., Yonemura,S., and Tsukita,Sa. 1993.
Submembranous junctional plaque proteins include potential tumor suppressor
molecules.
J.Cell Biol. 123:1049-1053.
Furuse,M., Hirase,T., Itoh,M., Nagafuchi,A., Yonemura,S., Tsukita,Sa., and
Tsukita,Sh. 1993.
Occludin: A novel integral membrane protein localizing at tight junctions
J.Cell Biol. 123:1777-1788.
Takeuchi,K., Sato,N., Kasahara,H., Funayama,N., Nagafuchi,A., Yonemura,S.,
Tsukita,Sa., and Tsukita,Sh. 1994.
Perturbation of cell adhesion and microvilli formation by antisense
oligonuclotides to ERM family members.
Tsukita,Sa., Oishi,K., Sato,N., Sagara,J., Kawai,A., and Tsukita,Sh. 1994.
ERM family members as molecular linkers between the cell surface
glycoprotein CD44 and actin-based cytoskeletons.
J.Cell Biol. 126:391-401.
Nagafuchi,A., Ishihara,S., and Tsukita,Sh. 1994.
The roles of catenins in the cadherin-mediated cell adhesion: Functional
analysis of E-cadherin-α catenin fusion molecules.
J.Cell Biol. 127:235-245.
Furuse,M., Itoh,M., Hirase,T., Nagafuchi,A., Yonemura,S., Tsukita,Sa., and
Tsukita,Sh. 1994.
Direct association of occludin with ZO-1 and its possible involvement in the
localization of occludin at tight junctions.
J.Cell Biol. 127:1617-1626.
Yonemura,S., Itoh,M., Nagafuchi,A., and Tsukita,Sh. 1995.
Cell-to-cell adherens junction formation and actin filament organization:
Similarities and difference between non-polarized fibroblasts and polarized
epithelial cells.
J.Cell Sci. 108:127-142.
Takeda,H., Nagafuchi,A., Yonemura,S., Tsukita,Sa., Behrens,J., Birchimeier,W.
and Tsukita,Sh. 1995.
V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak
state and b-catenin is not required for the shift.
J.Cell Biol. 131:1839-1847.
Ando-Akatsuka,Y., Saitou,M., Hirase,T., Kishi,M., Sakakibara,A., Itoh,M.,
Yonemura,S., Furuse,M., Tsukita,Sh. 1996.
Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse,
dog and rat-kangaroo homologues.
J.Cell Biol. 133:43-47.
Hirao,M., Sato,N., Kondo,T., Yonemura,S., Monden,M., Sasaki, T., Takai,Y.,
Tsukita,Sh. and Tsukita,Sa. 1996.
Regulation mecanism of ERM(Ezrin/Radixin/Moesin) protein/plasma membrane
association: Possible involvement of phosphatidylinositol turnover and Rho-
dependent signaling pathway.
J.Cell Biol. 135:37-51.
Tsukita,Sa., Yonemura,S. and Tsukita,Sh. 1997.
ERM (Ezrin/Radixin/Moesin) family: From cytoskeleton to signal transduction.
Curr.Opin.Cell Biol. 9:70-75 .
Tsukita,Sa., Yonemura,S., and Tsukita,Sh. 1997.
ERM proteins: Head-to-tail regulation of actin/plasma membrane regulations.
TIBS 22:53-58.
Sakakibara,A., Furuse,M., Saitou,M., Ando-Akatsuka,Y., and Tsukita,Sh. 1997.
Possible involvement of phosphorylation of occludin in tight junction formation.
J.Cell Biol. 137:1393-1401.
Itoh,M., Nagafuchi,A., Moroi,S. and Tsukita,Sh. 1997.
Involvement of ZO-1 in cadhherin-based cell adhesion through its direct binding to
a catenin and actin filaments.
J.Cell Biol. 138:181-192.
Kondo,T., Takeuchi,K., Doi,Y., Yonemura,S., Nagata,S., Tsukita,Sh., and Tsukita,Sa.
1997.
ERM (Ezrin/Radixin/Moesin)-based molecular mechanism of microvillar breakdown
at an early stage of apoptosis.
J.Cell Biol. 139:749-758.
Yonemura,S., Hirao,M., Doi,Y., Tsukita,Sa., and Tsukita,Sh. 1998.
ERM proteins bind to a specific group of integral membrane proteins containing a
positively-charged amino acid cluster in their juxta-membrane cytoplasmic domain.
J.Cell Biol. 140:885-895.
Matsui,T., Maeda,M., Yonemura,S., Amano,M., Kaibuchi,K., Tsukita,Sa., and Tsukita,Sh.
1998.
Rho-kinase phosphorylates carboxy-terminal threonines of ERM proteins and regulates
their head-to-tail association.
J.Cell Biol. 140:647-657.
Saitou,M., Fujimoto,K., Doi,Y.,Itoh,M., Fujimoto,T., Furuse,M., Takano,H., Noda,T.
and Tsukita,Sh. 1998.
Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells
bearing tight junctions.
J.Cell Biol. 141:397-408.
Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K., and Tsukita,Sh. 1998.
Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no
sequence similarity to occludin.
J.Cell Biol. 141:1539-1550.
Furuse,M., Sasaki,H., Fujimoto,K., and Tsukita,Sh. 1998.
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits
occludin in fibroblasts.
J.Cell Biol. 143:391-401.
Morita,K., Furuse,M., Fujimoto,K., and Tsukita,Sh. 1999.
Claudin multigene family encoding four-transmembrane domain protein components of
tight junction strands.
Proc.Natl.Acad.Sci.USA 96:511-516.
Doi,Y., Itoh,M., Yonemura,S., Ishihara,S., Takano,H., Noda,T., Tsukita,Sh., and
Tsukita,Sa. 1999.
Moesin gene knockout: Normal development of mice and unimpaired cell adhesion/cell
motility/actin-based cytoskeleton without compensatory up-regulation of ezrin and radixin.
J.Biol.Chem. 274:2315-2321.
Shiina,N. and Tsukita,Sh. 1999.
Mutations at phosphorylation sites of Xenopus microtubule-associated protein 4 affect
its microtubule-binding ability and chromosome movement during mitosis.
Mol.Biol.Cell 10:597-608.
Itoh,M., Morita,K. and Tsukita,Sh. 1999.
Characterization of ZO-2 as a MAGUK family member associated with tight and adherens
junctions with a binding affinity to occludin and a catenin.
J.Biol.Chem. 274:5981-5986.
Yonemura,S., Tsukita,Sa., and Tsukita,Sh. 1999.
Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the
organization of microvilli in collaboration with activated ERM proteins.
J.Cell Biol. 145:1497-1506.
Morita,K., Sasaki,H., Fujimoto,K., Furuse,M., and Tsukita,Sh. 1999.
Claudin-11/OSP-based tight junctions in myelinated sheaths of oligodendrocytes and in
Sertoli cells in testis.
J.Cell Biol. 145:579-588.
Imamura,Y., Itoh,M., Maeno,Y., Tsukita,Sh. and Nagafuchi,A. 1999.
Functional domains of a catenin required for the strong-state of cadherin-based cell adhesion.
J.Cell Biol. 144:1311-1322.
Tsukita,Sh. and Furuse,M. 1999.
Occludin and claudins in tight junction strands: Leading or supporting palyers?
Trends Cell Biol. 9:268-273.
Tsukita,Sh., Furuse,M., and Itoh,M. 1999.
Structural and signaling molecules come together at tight junctions.
Curr.Opin.Cell Biol. 11:628-633.
Furuse,M., Sasaki,H., and Tsukita,Sh. 1999.
Manner of interaction of heterogeneous claudin species within and between tight
junction strands.
J.Cell Biol. 147:891-903.
Itoh,M., Furuse,M., Morita,K., Kubota,K., and Tsukita,Sh. 1999.
Molecular basis for the recruitment of three MAGUKs, ZO-1, ZO-2 and ZO-3, to tight
junctions: Direct binding of their first PDZ domains to the COOH-termini of claudins.
J.Cell Biol. 147:1351-1363.
Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A., and Tsukita,Sh. 1999.
Ca++-independent cell adhesion activity of claudins, integral membrane proteins of
tight junctions.
Curr. Biol. 9:1035-1038.
Kubo,A., Sasaki,H., Yuba-Kubo,A., Tsukita,Sh., and Shiina,N. 1999.
Centriolar satellites: Molecular characterization, ATP-dependent movement toward centrioles
and possible involvement in ciliogenesis.
J.Cell Biol. 147:969-980.
Matsui,T., Yonemura,S., Tsukita,Sh. and Tsukita,Sa. 1999.
Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate
5-kinase and not ROCK kinases.
Curr. Biol. 9:1259-1262.
Sonoda,N., Furuse,M., Sasaki,H., Yonemura,S., Katahira,J., Horiguchi,Y., and Tsukita,Sh. 1999.
Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction
strands: Evidence for direct involvement of claudins in tight junction barrier.
J.Cell Biol. 147:195-204.
Hiiragi,T., Sasaki,H., Nagafuchi,A., Sabe,H., Shen,S.C., Matsu ki,M., Yamanishi,K.,
and Tsukita,Sh. 1999.
Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions
in simple epithelial cells.
J.Biol.Chem. 274:34148-34154.
Morita,K., Sasaki,H., Furuse,M. and Tsukita,Sh. 1999.
Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells.
J.Cell Biol. 147:185-194.
Mimori-Kiyosue,Y., Shiina,N., and Tsukita,Sh. 2000.
Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates
at their growing ends in epithelial cells.
J.Cell Biol. 148:505-518
Tsukita,Sh. and M.Furuse 2000.
Pores tin the wall: Claudins constitute tight junction strands containing aqueous pores.
J.Cell Biol. 149:13-16
Mimori-Kiyosue,Y., Shiina,N., and Tsukita,Sh. 2000.
The dynamic behavior of EB1, an Adenomatous Poliposis Coli (APC) binding protein,
on the distal ends of microtubules.
Curr. Biol. 10:865-868.
Sitou,M., Furuse,M., Sasaki,H., Schulzke,J., Fromm,M., Takano,H., Noda,T., and
Tsukita,Sh. 2000.
Complex phenotype of mice lacking occludin, a component of tight junction strands.
Mol.Biol.Cell 11:4131-4142.
Furuse,M., Furuse,K., Sasaki,H., and Tsukita,Sh. 2001.
Conversion of Zonula Occludentes from tight to leaky strand type by introducing claudin-2
into MDCK I cells.
J.Cell Biol. 153:263-272.
Oda,H. and Tsukita,Sh. 2001.
Real-time imaging of cell-cell adherens junctions reveals that Drosophila mesoderm
invagination begins with two phases of apical constriction of cells.
J.Cell Sci. 114:493-501.
Tsukita,Sh., Furuse,M. and Itoh,M. 2001.
Multi-functional strands in tight junctions.
Nature Rev.Mol.Cell Biol. 2:285-293.
Nakagawa,Y., Yamane,Y., Okanoue,T., Tsukita,Sh., and Tsukita,Sa. 2001.
Outer dense fiber 2 is a widespread centrosome scaffold component preferentially
associated with mother centrioles: Its identification from isolated centrosomes.
Mol.Biol.Cell 12:1687-1697
Ishikawa,H., Tamura,A., Matsui,T., Sasaki,H., Hakoshima,T., Tsukita,Sh., and Tsukita,Sa. 2001.
Structural conversion between open and closed forms of radixin: Low-angle shadowing
electron microscopy.
J.Mol.Biol. 310:973-978
Itoh,M., Sasaki,H., Furuse,M., Ozaki,H., Kita,T. and Tsukita,Sh. 2001.
Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the
recruitment of PAR-3 to tight junctions.
J.Cell Biol. 154:491-497
Mimori-Kiyosue,Y. and Tsukita,Sh. 2001.
Where is APC going?
J.Cell Biol. 154:1105-1109
Hamazaki,Y., Itoh,M., Mikio,F. and Tsukita,Sh. 2002.
Multi-PDZ-containing protein 1 (MUPP1) is concentrated at tight junctions through its
possible interaction.
J.Biol.Chem. 277:455-461.
Kiuchi-Saishin,Y., Furuse,M., Takasuga,A. and Tsukita,Sh. 2002.
Differential patterns of expression of claudin isoforms, tight junction membrane proteins,
in mouse nephron segments.
J.Am.Soc.Nephrol. 13:875-886.
Furuse,M., Hata,M., Furuse,K., Yoshida,Y., Haratake,A., Sugitani,Y., Noda,T., Kubo,A.
and Tsukita,Sh. 2002.
Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson
from claudin-1-deficient mice.
J.Cell Biol. 156:1099-1111.
Kikuchi,S., Hata,M., Fukumoto,K., Yamane,Y., Matsui,T., Tamura,A., Yonemura,S.,
Yamagishi,H., Keppler,D., Tsukita,Sh., Tsukita,Sa. 2002.
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile
canalicular membranes.
Nat.Genet. 31:320-325.
Tsukita,Sh. and Furuse,M. 2002.
Claudin-based barrier in simple and stratified cellular sheets.
Curr.Opin.Cell Biol. 14:531-536.
Kubo,A., and Tsukita,Sh. 2003.
Centriolar satellites consisting of PCM-1: Subcellular distribution and cell cycle-dependent
assembly/disassembly.
J.Cell Sci. 116:919-928.
Ikenouchi,J., Matsuda,M., Furuse,M. and Tsukita,Sh. 2003.
Regulation of tight junctions during epithelial-mesenchymal transition: Direct repression of
the gene expression of claudins/occludin by Snail.
J.Cell Sci. 116:1959-1967.
Sasaki,H., Matsui,C., Furuse,K., Mimori-Kiyosue,Y., Furuse,M. and Tsukita,Sh. 2003.
Dynamic behavior of paired claudin strands within apposing plasma membranes.
Proc.Natl.Acad.Sci.USA 100:3971-3976.
Nitta,T., Hata,M., Gotoh,S., Seo,Y., Sasaki,H., Hashimoto,N., Furuse,M. and
Tsukita,Sh. 2003.
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice.
J.Cell Biol. 161:653-660.
Asano,A., Asano,K., Sasaki,H., Furuse,M. and Tsukita,Sh. 2003.
Claudins in Caenorhabditis elegans: their distribution and barrier function in the epithelium.
Curr. Biol. 13:1042-1046.
（２００３年８月の時点での主要な論文のリストです）