最近の発表論文

2001年4月現在

Nakagawa,Y., Yamane,Y., Okanoue,T., Tsukita,Sh., and Tsukita,Sa. Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: Its identification from isolated centrosomes.  Mol.Biol.Cell in press. (2001)

Tsukita,Sh., Furuse,M. and Itoh,M. Multifunctional strands in tight junctions. Nature Rev. Mol.Cell Biol.  2, 285-293 (2001)

Oda,H. and Tsukita,Sh.  Real-time imaging of cell-cell adherens junctions reveals that Drosophila mesoderm invagination begins with two phases of apical constriction of cells. J.Cell Sci. 114, 493-501 (2001) [ERATO]

Furuse,M., Furuse,K., Sasaki,H., Tsukita,Sh. Conversion of Zonula Occludentes from tight to leaky strand type by introducing claudin-2 into MDCK I cells. J.Cell Biol. 153, 263-272 (2001)

Hirase,T., Kawashima,S., Wong,E.Y.M., Ueyama,T., Rikitake,Y., Tsukita,Sh., Yokoyama,M. and Staddon,J.M. Regulation of tight junction permeability and occludin phosphorylation by RhoA-p160ROCK-dependent and -independent mechanisms.  J.Biol.Chem.  276, 10432-10431 (2001)


Akiyama-Oda, Y., Hotta, Y., Tsukita, Sh., and Oda, H.  Mechanism of glia-neuron cell-fate switch in the Drosophila thoracic neuroblast 6-4 lineage. Development 127, 3513-3522 (2000) [ERATO]

Hamada, K., Matsui ,T., Tsukita, Sa., Tsukita, Sh., Hakoshima, T.
Crystallographic characterization of the membrane-binding domain of radixin. Acta Crystallogr D Biol Crystallogr. 56, 922-923 (2000)

Xiao S, Komiya K, Tochikura TS, Sagara J, Tsukita Sh., Kawai A. The rabies virion-associated 100-kDa polypeptide (VAP100) is a host-derived minor component of the viral envelope. Microbiol.Immunol. 44, 657-668 (2000)

Hamada,K., Shimizu,T., Matsui,T., Tsukita,Sa., Tsukita,Sh. and Hakoshima,T. Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J. 19, 4449-4462 (2000)

Tsukita,Sh. Tight junctions involving occludin and claudins.  Cornea  19, S142-S145 (2000)

Sitou,M., Furuse,M., Sasaki,H., Schulzke,J., Fromm,M., Takano,H., Noda,T., and Tsukita,Sh.  Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol.Biol.Cell 11, 4131-4142 (2000)

Akiyama-Oda,Y., Hotta,Y., Tsukita,Sh., and Oda,H. Distinct mechanisms triggering cell differentiation in Drosophila thoracic and abdominal neuroblasts 6-4.  Develop. Biol. 222, 429-439 (2000)[ERATO]

Tachibana,K., Nakanishi,H., Mandai,K., Ozaki,K., Ikeda,W., Yamamoto,Y., Nagafuchi,A., Tsukita,Sh., and Takai,Y.  Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J.Cell Biol. 150, 1161-1176 (2000)

Fujita,K., Katahira,J., Horiguchi,Y., Sonoda,N., Furuse,M., and Tsukita,Sh.  Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein.  FEBS Let. 476, 258-261 (2000)

Mimori-Kiyosue,Y., Shiina,N., and Tsukita,Sh.  The dynamic behavior of EB1, an Adenomatous Poliposis Coli (APC) binding protein, on the distal ends of microtubules.   Curr.Biol. 10, 865-868 (2000)[ERATO]

Takahashi,N., Ishihara,S., Takada,S., Tsukita,Sh., and Nagafuchi,A.  Posttranscriptional regulation of alpha-catenin expression is required for Wnt signaling in L cells.  BBRC 277, 691-698 (2000)

Tsukita,Sh. and Furuse,M. Pores in the wall: Claudin constitutes tight junctions strands containing aqueous proes. J.Cell Biol. 149, 13-16 (2000)

Tsukita,Sh. and Furuse,M. The structure and function of claudins, cell adhesion molecules at tight junctions.  Ann.NY Acad.Sci. 915, 129-135 (2000) 

Mimori-Kiyosue,Y., Shiina,N., and Tsukita,Sh. Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells. J.Cell Biol. 148, 505-518 (2000) [ERATO]


Tsukita,Sa. and Yonemura,S. Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins.  J.Biol.Chem. 274, 34507-34510 (1999)

【発表当時の説明】Hiiragi,T., Sasaki,H., Nagafuchi,A., Sabe,H., Shen,S.C., Matsu ki,M., Yamanishi,K., and Tsukita,Sh. Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells. J.Biol.Chem. 274, 34148-34154 (1999)

Furuse,M., Sasaki,H., and Tsukita,Sh. Manner of interaction of heterogenous claudin species within and between tight junction strands. J.Cell Biol. 147, 891-903 (1999)

Itoh,M., Furuse,M., Morita,K., Kubota,K., and Tsukita,Sh.  Molecular basis for the recruitment of three MAGUKs, ZO-1, ZO-2 and ZO-3, to tight junctions: Direct binding of their first PDZ domains to the COOH-termini of claudins. J.Cell Biol. 147, 1351-1363 (1999)

Oda,H., and Tsukita,Sh. Nonchordate classic cadherins have a structurally and functionally unique domain that is absent from chordate classic cadherins.  Dev.Biol. 216, 406-422 [ERATO]

Morita,K., Sasaki,H., Furuse,M. and Tsukita,Sh. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells.  J.Cell Biol. 147,185-194 (1999)

【発表当時の説明】Sonoda,N., Furuse,M., Sasaki,H., Yonemura,S., Katahira,J., Horiguchi,Y., and Tsukita,Sh. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.  J.Cell Biol.  147,195-2041 (1999)

Matsui,T., Yonemura,S., Tsukita,Sh. and Tsukita,Sa. Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases.  Curr.Biol. 9,1259-1262 (1999)

【発表当時の説明】Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A., and Tsukita,Sh. Ca++-independent cell adhesion activity of claudins, integral membrane proteins of tight junctions.  Curr.Biol. 9,1035-1038 (1999)

Tsukita,Sh., Furuse,M., and Itoh,M.  Structural and signaling molecules come together at tight junctions.  Curr.Opin.Cell Biol.  11, 628-633 (1999)

Yonemura,S., Tsukita,Sa., and Tsukita,Sh.   Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins.  J.Cell Biol.  145,1497-509 (1999)

Maeda,M., Matsui,T., Imamura,M., Tsukita,Sh. and Tsukita,Sa.   Expression level, subcellular distribution and Rho-GDI binding affinity of merlin in comparison with ezrin/radixin/moesin proteins.  Oncogene 18, 4788-4797 (1999)

Maeno,Y., Moroi,S., Nagashima,H., Noda,T., Shiozaki,H., Monden,M., Tsukita,Sh. and Nagafuchi,A.  Alpha-catenin-deficient F9 cells differentiate into signet ring cells.  Am.J.Pathol. 154,1323-1328  (1999)

Tsukita,Sh. and Furuse,M.  Occludin and claudins in tight junction strands: Leading or supporting palyers ?  Trends Cell Biol.  9,268-273 (1999)

【発表当時の説明】Imamura,Y., Itoh,M., Maeno,Y., Tsukita,Sh. and Nagafuchi,A.  Functional domains of alpha catenin required for the strong-state of cadherin-based cell adhesion.  J.Cell Biol. 144,1311-1322 (1999)

Verkhusha,V.V., Tsukita, Sh., Oda, H.  Actin dynamics in lamellipodia of migrating border cells in the Drosophila overy revealed by a GFP-actin fusion protein. FEBS Let. 445,395-401  (1999) [ERATO]

Oda,H. and Tsukita,Sh.  Dynamic features of adherens junctions during Drosophila embryonic epithelial morphogenesis revealed by a Dalpha-cantein-GFP fuion protein.  Dev.Genes.Evol.  209,218-225. [ERATO]

Hayashi,K., Yonemura,S., Matsui,T., Tsukita,Sa. and Tsukita,Sh.  Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues: Application of a novel fixation protocol using trichloroacetic acids (TCA) as a fixative.  J.Cell Sci.  112,1149-1158  (1999)

【発表当時の説明】Morita,K., Sasaki,H., Fujimoto,K., Furuse,M., and Tsukita,Sh.  Claudin-11/OSP-based tight junctions in myelinated sheaths of oligodendrocytes and in Sertoli cells in testis.  J.Cell Biol.  145,579-588  (1999)

Shiina,N. and Tsukita,Sh.  Mutations at phosphorylation sites of Xenopus microtubule-associated protein 4 affect its microtubule-binding ability and chromosome movement during mitosis.  Mol.Biol.Cell 10,597-608. [ERATO]

Ando-Akatsuka,Y., Yonemura,S., Itoh,M., Furuse,M., and Tsukita,Sh.  Differential behavior of E-cadherin and occludin in their colocalization with ZO-1 during the establishment of epithelial cell polarity. J.Cell Physiol. 179,115-125 (1999)

【発表当時の説明】Itoh,M., Morita,K. and Tsukita,Sh.  Characterization of ZO-2 as a MAGUK family member associated with tight and adherens junctions with a binding affinity to occludin and alpha catenin.   J.Biol.Chem.   274,5981-5986 (1999)

【発表当時の説明】Doi,Y., Itoh,M., Yonemura,S., Ishihara,S., Takano,H., Noda,T., Tsukita,Sh., and Tsukita,Sa.  Moesin gene knockout: Normal development of mice and unimpaired cell adhesion/cell motiltiy/actin-based cytoskeleton without compensatory up-regulation of ezrin and radixin.   J.Biol.Chem.  274,2315-2321 (1999)

【発表当時の説明】Morita,K., Furuse,M., Fujimoto,K., and Tsukita,Sh.  Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.  Proc.Natl.Acad.Sci.USA.   96,511-516 (1999)


Tsukita,Sh., and Furuse,M.  Overcoming barriers in the study of tight junction functions: from occludin to claudin. Genes Cells.  3,569-573 (1998)

【発表当時の説明】Furuse,M., Sasaki,H., Fujimoto,K., and Tsukita,Sh.  A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts.  J.Cell Biol.  143,391-401  (1998).

Oda,H., Tsukita,Sh., and Takeichi,M.  Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastration.  Dev.Biol.   203,435-450  (1998)

【発表当時の説明】Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K., and Tsukita,Sh.  Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin.  J.Cell Biol.  141,1539-1550  (1998)

Moroi,S., Saitou,M., Fujimoto,K., Sakakibara,A., Furuse,M., Yoshida,O., and Tsukita,Sh. Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes. Am.J.Physiol. 274,C1708-C1717 (1998)

【発表当時の説明】Saitou,M., Fujimoto,K., Doi,Y.,Itoh,M., Fujimoto,T., Furuse,M., Takano,H.,Noda,T. and Tsukita,Sh. Occludin-deficient embryonic stem cells can diferentiate into polarized epithelial cells bearing tight junctions.  J.Cell Biol. , 141,397-408 (1998)

Morita,K., Itoh,M., Saitou,M., Ando-Akatsuka,Y., Furuse,M., Yoneda,K., Imamura,S., and Tsukita,Sh.  Subcellular distribution of tight junction-associated proteins, occludin, ZO-1 and ZO-2, in rodent skin and its developmental changes.  J.Inv.Dermatol.  110,862-866 (1998).

Sako,Y., Nagafuchi,A., Tsukita,Sh., Takeichi,M. and Kusumi,A.  Cytoplasmic regulation of the movement of E-cadherin on the free cell surface as studied by optical tweezers and single particle tracking: corralling and tethering by the membrane skeleton
J.Cell Biol. 140,1227-1240  (1998).

【発表当時の説明】Matsui,T., Maeda,M., Yonemura,S., Amano,M., Kaibuchi,K., Tsukita,Sa., and Tsukita,Sh. Rho-kinase phosphorylates carboxy-terminal threonines of ERM proteins and regulates their head-to-tail association.  J.Cell Biol. 140, 647-657 (1998)

【発表当時の説明】Yonemura,S., Hirao,M., Doi,Y., Tsukita,Sa., and Tsukita,Sh. ERM proteins bind to a specific group of integral membrane proteins containing a positively-charged amino acid cluster in their juxta-membrane cytoplasmic domain. J.Cell Biol. 140, 885-895 (1998).

Doi, Y., Kurita,M., Matsumoto,M., Kondo,T., Noda,T., Tsukita,Sa., Tsukita,Sh. and Seya,T. Moesin is not a receptor for measles virus entry into mouse embryonic stem cells. J.Virol. 72, 1586-1592 (1998)


【発表当時の説明】Kondo,T., Takeuchi,K., Doi,Y., Yonemura,S., Nagata,S., Tsukita,Sh., Tsukita,Sa. ERM (Ezrin/Radixin/Moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis. J.Cell Biol., 139, 749-758 (1997)

Hirase,T., Furuse,M., Tsukita,Sh. A 155kDa undercoat-constitutive protein of cell-to-cell adherens junctions. Eur.J.Cell Biol., 72, 174-181(1997)

Saitou,M., Akatsuka-Ando,Y., Itoh,M., Furuse,M., Inazawa,J., Fujimoto,K., and Tsukita,Sh. Mammalian occludin in epithelial cells: Its expression and subcellular distribution. Eur.J.Cell Biol., 73, 222-231(1997)

Takahashi,K., Sasaki,T., Mammoto,A., Takaishi,K., Kameyama,T., Tsukita,Sa., Tsukita,Sh., and Takai,Y. Direct interaction of the rho GDP dissociation inhibitor with Ezrin/Radixin/Moesin initiates the activation of the rho small G protein. J.Biol.Chem. 272, 23371-23375 (1997)

Mandai,K., Nakanishi,H., Satoh,A., Obaishi,H., Wada,M., Nishioka,H., Itoh,M., Aoki,T., Fujimoto,T., Matsuda,Y., Mizoguchi,A., Tsukita,Sh., Takai,Y. Afladin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J.Cell Biol. , 139, 517-528 (1997)

【発表当時の説明】Tsukita,Sa., Yonemura,S. and Tsukita,Sh. ERM (Ezrin/Radixin/Moesin) Family: From Cytoskeleton to Signal Transduction. Curr.Opin.Cell Biol., 9, 70-75(1997)

【発表当時の説明】Tsukita,Sa., Yonemura,S., and Tsukita,Sh. ERM proteins: Head-to-tail regulation of actin/plasma membrane regulations. TIBS, 22, 53-58(1997)

【発表当時の説明】Sakakibara,A., Furuse,M., Saitou,M., Ando-Akatsuka,Y., and Tsukita,Sh. Possible involvement of phosphorylation of occludin in tight junction formation. J.Cell Biol., 137, 1393-1401(1997)

Fujimoto,K., Nagafuchi,A., Tsukita,Sh., Kuraoka,A., Ohokuma,A., Shibata,Y. Dynamics of connexins, E-cadherin and alpha-catenin on the cell membranes during the gap junction formation. J.Cell Sci., 110, 311-322 (1997)

Hirase,T., Staddon,J.M., Saitou,M., Akatsuka-Ando,Y., Itoh,M., Furuse,M., Fujimoto,K., Tsukita,Sh., Rubin,L. Occludin as a possible determinant of tight junction permeability in endothelial cells. J.Cell Sci., 110, 1603-1613(1997)

【発表当時の説明】Itoh,M., Nagafuchi,A. and Tsukita,Sh. Involvement of ZO-1 in cadhherin-based cell adhesion through its direct binding to a catenin and actin filaments. J.Cell Biol. 138, 181-192 (1997)

Kimura,Y., Shiozaki,H., Hirao,M., Maeno,Y., Doki,Y., Inoue,M., Monden,T., Ando-Akatsuka,Y., Furuse,M, Tsukita,Sh., and Monden,M. Expression of occludin, tight junction-associated protein, in human digestive tract. Am.J.Pathol., 151, 45-54 (1997)

Sagara,J., Tochikura,T.S., Yamamoto,T., Tsukita,Sh., Tsukita,Sa., Kawai,A.  Immunological studies of a 21 kDa cellular component efficiently incorporated into Rabies virion grown in a BHK-21 cell culture. Microbiol. Immunol. 41,947-955 (1997)


Furuse,M., Fujimoto,K.., Sato,N., Hirase,T., Tsukita,Sa., and Tsukita,Sh. Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. J.Cell Sci., 109, 429-435(1996)

Tokai,N., Fujimoto-Nishiyama,A., Toyoshima,Y., Yonemura,S., Tsukita,Sh., Inoue,J., and Yamamoto,T. Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. EMBO J., 15, 457-467(1996)

Ando-Akatsuka,Y., Saitou,M., Hirase,T., Kishi,M., Sakakibara,A., Itoh,M., Yonemura,S., Furuse,M., Tsukita,Sh. Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog and rat-kangaroo homologues. J.Cell Biol., 133, 43-47(1996)

Hirao,M., Sato,N., Kondo,T., Yonemura,S., Monden,M., Sasaki, T., Takai,Y., Tsukita,Sh. and Tsukita,Sa. Regulation Mecanism of ERM(Ezrin/Radixin/Moesin) Protein/Plasma Membrane Association: Possible Involvement of Phosphatidylinositol Turnover and Rho-dependent Signaling Pathway. J.Cell Biol., 135, 37-51 (1996)

McCarthy, K.M., Skare,I.B., Stankewich,M.C., Furuse,M., Tsukita,Sh., Rogers,R.A., Lynch,R.D., and Schneeberger,E.E. Occludin is a functional component of the tight juncton. J.Cell Sci., 109, 2287-2298 (1996)

Tsukita,Sh., Furuse,M., Itoh,M. Molecular dissection of tight junctions. Cell Struct. Funct., 21, 381- 385(1996)


Yonemura,S., Itoh,M., Nagafuchi,A., and Tsukita,Sh. Cell-to-cell adherens junction formation and actin filament organization: Similarities and difference between non-polarized fibroblasts and polarized epithelial cells. J.Cell Sci., 108, 127-142(1995)

Sagara,J., Tsukita,Sa., Yonemura,S., Tsukita,Sh., and Kawai,A. Cellular actin-binding ezrin-radixin-moesin (ERM) family proteins are incorporated into the rabies virion and closely associated with viral envelope proteins in the cell. Virology, 206, 485-494(1995)

Takaishi,K., Sasaki,T., Kameyama,T., Tsukita,Sa., Tsukita,Sh., and Takai,Y. Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites, and cleavage furrows. Oncogene, 11, 39-48(1995)

Yasui,W., Kuniyasu,H., Akama,Y., Kitahara,K., Nagafuchi,A., Ishihara,S., Tsukita,Sh., and Tahara,E. Expression of E-cadherin, alpha- and beta-cateninsin human gastric carcinomas: Correlation with histology and tumor progression. Oncology Res., 2, 111-117(1995)

Oyama,T., Knai,Y., Ochiai,A., Akimoto,S., Oda,T., Yanagihara,K., Nagafuchi,A., Tsukita,Sh., Shibamoto,S., Ito,F., Takeichi,M., Matsuda,H., and Hirohashi,S. A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: A cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res., 54, 6282-6287(1995)

Takeda,H., and Tsukita,Sh. Effects of tyrosine phosphorylation on tight junctions in temperature-sensitive v-src-transfected MDCK cells. Cell Struct.Funct., 20, 387-393(1995)

Takeda,H., Nagafuchi,A., Yonemura,S., Tsukita,Sa., Behrens,J., Birchimeier,W. and Tsukita,Sh. V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta-catenin is not required for the shift. J.Cell Biol., 131, 1839-1847(1995)


Ochiai,A., Akimoto,S., Shimoyama,Y., Nagafuchi,A., Tsukita,Sh., and Hirohashi,S. Selective loss of alpha-catenin expression in scirrhous carcinomas with scattered cell growth. Jap.J.Cancer Res., 85, 266-273 (1994)

Nagafuchi,A., and Tsukita,Sh. The nervous tissue-specific loss of the expression of alpha-catenin, the102kD cadherin-associated protein, during development. Develop.Growth & Differ., 36, 59-71 (1994)

Kishino,T., Ariga,T., Soejima,H., Tamura,T., Ohta,T., Jinno,Y., Yonemura,S.Sato,N., Tsukita,Sa., Tsukita,Sh., Sakiyama,Y., and Niikawa,N. Assignment of the human moesin gene(MSN) to chromosome region Xq11.2-q12. Cytogenet.Cell Genet., 66, 167-169 (1994)

Shiozaki,H., Iihara,K., Oka,H., Kadowaki,T., Matsui,S., Gofuku,J., Inoue,M.Nagafuchi,A., Tsukita,Sh., and Mori,T. Immunohistochemical detection of alpha-catenin expression in human cancers. Am.J.Pathol., 144, 667-674(1994)

Takeuchi,K., Sato,N., Kasahara,H., Funayama,N., Nagafuchi,A., Yonemura,S., Tsukita,Sa., and Tsukita,Sh. Perturbation of cell adhesion and microvilli formation by antisense oligonuclotides to ERM family members. J.Cell Biol., 125, 1371-1384 (1994)

Takeuchi,K., Kawashima,A., Nagafuchi,A. and Tsukita,Sh. Structural diversity of band 4.1 superfamily members. J.Cell Sci., 107, 1921-1928 (1994)

Tsukita,Sa., Oishi,K., Sato,N., Sagara,J., Kawai,A., and Tsukita,Sh. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J.Cell Biol., 126, 391-401 (1994)

Nagafuchi,A., Ishihara,S., and Tsukita,Sh. The roles of catenins in the cadherin-mediated cell adhesion: Functional analysis of E-cadherin-alpha catenin fusion molecules. J.Cell Biol., 127, 235-245 (1994)

Kasahara,H., Itoh,M., Sugiyama,T., Kido,N., Hayashi,H., Saito,H., Tsukita,Sh., and Kato,N. Autoimmune myocarditis induced in mice by c-protein. J.Clin.Invest., 94, 1026-1036(1994)

Matsui,S., Shiozaki,H., Inoue,M., Tamura,S., Doki,Y., Kadowaki,T., Iwazawa,T., Shimaya,K., Nagafuchi,A., Tsukita,Sh., and Mori,T. Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer. Virchows Archiv, 424, 375-381(1994)

Furuse,M., Itoh,M., Hirase,T., Nagafuchi,A., Yonemura,S., Tsukita,Sa., and Tsukita,Sh. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J.Cell Biol., 127, 1617-1626(1994)

Oyama,T., Kanai,Y.,Ochiai,A., Akimoto,S., Oda,T., Yangihara,K.,Nagafuchi,A.Tsukita,Sh., Shibamoto,S., Ito,F., Takeichi,M., Matsuda,H., and Hirohashi,S. A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: A cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res., 54, 6282-6287(1994)


Yonemura,S., Nagafuchi,A., Sato,N., and Tsukita,Sh. Concentration of an integral membrane protein, CD43 (leukosialin,sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons. J.Cell Biol.,120, 437-449(1993)

Funatsu,T., Kono,E., Higuchi,H., Kimura,S., Ishiwata,S., Yoshioka,T., Maruyama,K., and Tsukita,Sh. Elastic filaments in situ in cardiac muscle: Deep-etch replica analysis in combination with selective removal of actin and myosin filaments. J.Cell Biol., 120, 711-724(1993)

Itoh,M., Nagafuchi,A., Yonemura,S., Yasuda-Kitani,T., Tsukita,Sa., and Tsukita,Sh. The 220kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J.Cell Biol., 121, 491-502(1993)

Funatsu,T., Kono,E., and Tsukita,Sh. Time-resolved electron microscopic analysis of the behavior of myosin heads on actin filaments after photolysis of caged ATP. J.Cell Biol., 121, 1053-1064(1993)

Oda,H., Uemura,T., Shiomi,K., Nagafuchi,A., Tsukita,Sh., and Takeichi,M. Identification of a Drosophila homologue of alpha-catenin and its association with the armadillo protein. J.Cell Biol.,121, 1133-1140(1993)

Tsukita,Sh., Itoh,M., Nagafuchi,A., Yonemura,S., and Tsukita,Sa. Submembranous junctional plaque proteins include potential tumor suppressor molecules., J.Cell Biol., 123, 1049-1053(1993)

Oda,T., Kanai,Y., Shimoyama,Y., Nagafuchi,A., Tsukita,Sh and Hirohashi,S. Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line. BBRC, 193, 897-904 (1993)

Morton,R.A., Ewing,C.M., Nagafuchi,A., Tsukita,Sh., and Isaacs,W.B. Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells. Cancer Res., 53, 3585-3590(1993)

Furukawa,Y., Nakatsuru,S., Nagafuchi,A., Tsukita,Sh., Muto,T., Nakamura,Y.,and Horii,A. Structure, expression and chromosomal assignment of the human alpha-catenin gene. Cytogenetics & Cell Genetics, 65, 74-78(1993)

Hashimoto,T., Amagai,M, Parry,D.A.D., Dixon,T.W., Tsukita,Sa., Tsukita,Sh.,Miki,K., Sakai,K., Inokuchi,Y., Kudoh,J., Shimizu,N., and Nishikawa,T. Desmoyokin, a 680 kDa keratinocyte plasma membrane-associated protein, is homologous to the protein encoded by human gene AHNAK. J.Cell Sci., 105, 275-286(1993)

Kadowaki,T., Shiozaki,H., Inoue,M., Tamura,S., Oka,H., Doki,Y., Iihara,K., Matsui,S., Iwazawa,T., Nagafuchi,A., Tsukita,Sh., and Mori,T. E-cadherin and alpha-catenin expression in human esophageal cancer. Cancer Res., 54, 291-296(1993)

Nagafuchi,A., Tsukita,Sh., and Takeichi,M. Transmembrane control of cadherin-mediated cell-cell adhesion. Seminars in Cell Biol., 14, 175-181(1993)

Furuse,M., Hirase,T., Itoh,M., Nagafuchi,A., Yonemura,S., Tsukita,Sa., and Tsukita,Sh. Occludin:A novel integral membrane protein localizing at tight junctions. J.Cell Biol., 123, 1777-1788(1993)


Sato,N., Funayama,N., Nagafuchi,A., Yonemura,S., Tsukita,Sa., and Tsukita, Sh. A gene family consisting of ezrin, radixin, and moesin. Its specific localization at actin/plasma membrane association sites. J.Cell Sci., 103, 131-143(1992)

Matsuyoshi,N., Hamaguchi,M., Taniguchi,S., Nagafuchi,A., Tsukita,Sh., and Takeichi,M. Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts. J.Cell Biol., 118, 703- 714(1992)

Shimoyama,Y., Nagafuchi,A., Fujita,S., Gotoh,M., Takeichi,M., Tsukita, Sh., and Hirohashi,S. Cadherin dysfunction in a human cancer cell line: Possible involvement of loss of a-catenin expression in reduced cell-cell adhesiveness. Cancer Res., 52, 5770-5774(1992)

Tsukita,Sh., Tsukita,Sa., Nagafuchi,A., and Yonemura,Sh. Molecular linkage between cadherins and actin filaments in cell-to-cell adherens junctions. Curr.Opin.Cell Biol., 4, 834-839(1992)

Hosoya,H., Kobayashi,R., Tsukita,Sh., and Matsumura,F. Ca-regulated actin and phospholipid binding protein(68kD-protein) from bovine liver: Identification as a homologue for annexin VI and intra-cellular localization.; Cell Motility & Cytoskeleton, 22, 200-210(1992)

Fujiwara,S., Shinkai,H., Takayasu,S., Owaribe,K., Tsukita,Sh., and Kageshita,T. A case of subepidermal blister disease associated with autoantibody against 450kD protein. J.Dermatol., 19, 610-613(1992)